Human BAG2 Recombinant Protein (RPPB5850)

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SKU:
RPPB5850
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95816
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Description

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Product Name:Human BAG2 Recombinant Protein
Product Code:RPPB5850
Size:20µg
Species:Human
Target:BAG2
Synonyms:BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2, KIAA0576, MGC149462, dJ417I1.2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The BAG2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 20% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK TLQQNAESRF N

BCL2-associated athanogene 2 (BAG2) belongs to the Bag family of proteins. BAG2 is a chief component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to upset CHIP-mediated ubiquitylation. BAG proteins compete with Hip for attaching to the Hsc70/Hsp70 ATPase domain and promote substrate discharge. All the BAG proteins have a roughly 45 amino acid BAG domain by the C-terminus but vary clearly in their N-terminal regions. The BAG domains of BAG1, BAG2, and BAG3 act together expressly with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins attach with high affinity to the ATPase domain of Hsc70 and obstruct its chaperone activity in a Hip-repressible manner.

BAG2 Human Recombinant fused with a�20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�231 amino acids (1-211 a.a.) and having a molecular mass of 25.9kDa. The BAG2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 6p12.1-p11.2

Cellular Component: cytosol

Molecular Function:adenyl-nucleotide exchange factor activity; identical protein binding; protein binding

Biological Process: protein folding; protein metabolic process

NCBI Summary:BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
UniProt Code:O95816
NCBI GenInfo Identifier:12229698
NCBI Gene ID:9532
NCBI Accession:O95816.1
UniProt Secondary Accession:O95816,Q08AS9, Q6FID0, B4DXE2,
UniProt Related Accession:O95816
Molecular Weight:20,189 Da
NCBI Full Name:BAG family molecular chaperone regulator 2
NCBI Synonym Full Names:BCL2 associated athanogene 2
NCBI Official Symbol:BAG2��
NCBI Official Synonym Symbols:BAG-2; dJ417I1.2��
NCBI Protein Information:BAG family molecular chaperone regulator 2
UniProt Protein Name:BAG family molecular chaperone regulator 2
UniProt Synonym Protein Names:Bcl-2-associated athanogene 2
Protein Family:BAG family molecular chaperone regulator
UniProt Gene Name:BAG2��
UniProt Entry Name:BAG2_HUMAN
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