Anti-BAG2 Antibody (CAB8775)

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SKU:
CAB8775
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
BAG-2
Synonyms:
dJ417I1.2
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Description

抗体名:BAG2 Rabbit mAb
抗体コード:CAB8775
サイズ:20uL, 50uL, 100uL
同義語:BAG-2, dJ417I1.2
申し込み:WB, IHC
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human BAG2
申し込み:WB, IHC
推奨される希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:A-549, PC-3, Jurkat
免疫原:A synthesized peptide derived from human BAG2
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:9532
Uniprot:O95816
計算された分子量:24kDa
観察された分子量:24KDa
UniProt Protein Function:BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 6p12.1-p11.2

Cellular Component: cytosol

Molecular Function:adenyl-nucleotide exchange factor activity; identical protein binding; protein binding

Biological Process: protein folding; protein metabolic process

NCBI Summary:BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
UniProt Code:O95816
NCBI GenInfo Identifier:12229698
NCBI Gene ID:9532
NCBI Accession:O95816.1
UniProt Secondary Accession:O95816,Q08AS9, Q6FID0, B4DXE2,
UniProt Related Accession:O95816
Molecular Weight:20,189 Da
NCBI Full Name:BAG family molecular chaperone regulator 2
NCBI Synonym Full Names:BCL2 associated athanogene 2
NCBI Official Symbol:BAG2  
NCBI Official Synonym Symbols:BAG-2; dJ417I1.2  
NCBI Protein Information:BAG family molecular chaperone regulator 2
UniProt Protein Name:BAG family molecular chaperone regulator 2
UniProt Synonym Protein Names:Bcl-2-associated athanogene 2
Protein Family:BAG family molecular chaperone regulator
UniProt Gene Name:BAG2  
UniProt Entry Name:BAG2_HUMAN
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