HTR3A Antibody (PACO49674)
- SKU:
- PACO49674
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | HTR3A Antibody (PACO49674) |
抗体コード: | PACO49674 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human 5-hydroxytryptamine receptor 3A protein (322-455AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat lung tissue, Mouse lung tissue. All lanes: HTR3A antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 56, 59, 54, 60 kDa. Observed band size: 56 kDa.. | |
Immunofluorescent analysis of HepG2 cells using PACO49674 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
シノニム: | 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor), HTR3A, 5HT3R HTR3 |
UniProt Protein Function: | 5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gated Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; cell junction Molecular Function:serotonin binding; serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity; serotonin receptor activity; receptor activity Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway |
NCBI Summary: | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | P46098 |
NCBI GenInfo Identifier: | 1168222 |
NCBI Gene ID: | 3359 |
NCBI Accession: | P46098.1 |
UniProt Secondary Accession: | P46098,O60854, Q7KZM7, Q99918, Q9BSZ9, B4DSY6, G5E986 |
UniProt Related Accession: | P46098 |
Molecular Weight: | 478 |
NCBI Full Name: | 5-hydroxytryptamine receptor 3A |
NCBI Synonym Full Names: | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
NCBI Official Symbol: | HTR3A |
NCBI Official Synonym Symbols: | HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R |
NCBI Protein Information: | 5-hydroxytryptamine receptor 3A; 5-HT3-A; serotonin receptor 3A; 5HT3 serotonin receptor; serotonin-gated ion channel receptor |
UniProt Protein Name: | 5-hydroxytryptamine receptor 3A |
UniProt Synonym Protein Names: | 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor |
Protein Family: | 5-hydroxytryptamine receptor |
UniProt Gene Name: | HTR3A |
UniProt Entry Name: | 5HT3A_HUMAN |