FGG Antibody (PACO51506)
- SKU:
- PACO51506
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | FGG Antibody (PACO51506) |
抗体コード: | PACO51506 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Fibrinogen γ chain protein (278-437AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO51506 at dilution of 1:100. | |
Western Blot. Positive WB detected in: Mouse heart tissue. All lanes: FGG antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52, 50 kDa. Observed band size: 52 kDa. | |
Immunofluorescent analysis of Hela cells using PACO51506 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Together with fibrinogen α (FGA) and fibrinogen β (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. |
シノニム: | Fibrinogen γ chain, FGG |
UniProt Protein Function: | FGG: Fibrinogen has a double Function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q28 Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region; plasma membrane; cell cortex; external side of plasma membrane Molecular Function:protein binding, bridging; metal ion binding; cell adhesion molecule binding; structural molecule activity; receptor binding Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; platelet degranulation; cellular protein complex assembly; positive regulation of protein secretion; cell-matrix adhesion; positive regulation of vasoconstriction; response to calcium ion; blood coagulation; signal transduction; positive regulation of exocytosis Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital |
NCBI Summary: | The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | P02679 |
NCBI GenInfo Identifier: | 20178280 |
NCBI Gene ID: | 2266 |
NCBI Accession: | P02679.3 |
UniProt Secondary Accession: | P02679,P04469, P04470, Q53Y18, Q96A14, Q96KJ3, Q9UC62 Q9UC63, Q9UCF3, A8K057, |
UniProt Related Accession: | P02679 |
Molecular Weight: | 49,497 Da |
NCBI Full Name: | Fibrinogen gamma chain |
NCBI Synonym Full Names: | fibrinogen gamma chain |
NCBI Official Symbol: | FGG |
NCBI Protein Information: | fibrinogen gamma chain; fibrinogen, gamma polypeptide |
UniProt Protein Name: | Fibrinogen gamma chain |
Protein Family: | Fibrinogen |
UniProt Gene Name: | FGG |
UniProt Entry Name: | FIBG_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |