FGF17 Antibody (PACO16335)
- SKU:
- PACO16335
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | FGF17 Antibody (PACO16335) |
抗体コード: | PACO16335 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human FGF17 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: PACO16335(FGF17 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. |
バックグラウンド: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid, sequence and chromosomal localization are identical to FGF17. |
シノニム: | fibroblast growth factor 17 |
UniProt Protein Function: | FGF17: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 8p21 Cellular Component: extracellular region; extracellular space Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction Disease: Hypogonadotropic Hypogonadism 20 With Or Without Anosmia |
NCBI Summary: | This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Code: | O60258 |
NCBI GenInfo Identifier: | 6015147 |
NCBI Gene ID: | 8822 |
NCBI Accession: | O60258.1 |
UniProt Secondary Accession: | O60258,Q2M2W1, B7ZLG4, |
UniProt Related Accession: | O60258 |
Molecular Weight: | 23,669 Da |
NCBI Full Name: | Fibroblast growth factor 17 |
NCBI Synonym Full Names: | fibroblast growth factor 17 |
NCBI Official Symbol: | FGF17 |
NCBI Official Synonym Symbols: | HH20; FGF-13; FGF-17 |
NCBI Protein Information: | fibroblast growth factor 17 |
UniProt Protein Name: | Fibroblast growth factor 17 |
Protein Family: | Fibroblast growth factor |
UniProt Gene Name: | FGF17 |
UniProt Entry Name: | FGF17_HUMAN |