ESRRB Antibody (PACO57752)
- SKU:
- PACO57752
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ESRRB Antibody (PACO57752) |
抗体コード: | PACO57752 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
反応性: | Human |
免疫原: | Recombinant Human Steroid hormone receptor ERR2 protein (432-502AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate. All lanes: ESRRB antibody at 3.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 49, 57, 56 kDa. Observed band size: 49 kDa. |
バックグラウンド: | Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity). |
シノニム: | Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2), ESRRB, ERRB2 ESRL2 NR3B2 |
UniProt Protein Function: | ERR2: Nuclear receptor, may regulate ESR1 transcriptional activity. Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35). DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the nuclear hormone receptor family. NR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear receptor; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: nucleoplasm; nucleus Molecular Function:ligand-dependent nuclear receptor activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter Disease: Deafness, Autosomal Recessive 35 |
NCBI Summary: | This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95718 |
NCBI GenInfo Identifier: | 374095385 |
NCBI Gene ID: | 2103 |
NCBI Accession: | O95718.2 |
UniProt Secondary Accession: | O95718,Q5F0P7, Q5F0P8, Q9HCB4, A2VDJ2, B6ZGU4, |
UniProt Related Accession: | O95718 |
Molecular Weight: | 48,054 Da |
NCBI Full Name: | Steroid hormone receptor ERR2 |
NCBI Synonym Full Names: | estrogen related receptor beta |
NCBI Official Symbol: | ESRRB |
NCBI Official Synonym Symbols: | ERR2; ERRb; ESRL2; NR3B2; DFNB35 |
NCBI Protein Information: | steroid hormone receptor ERR2 |
UniProt Protein Name: | Steroid hormone receptor ERR2 |
UniProt Synonym Protein Names: | ERR beta-2; Estrogen receptor-like 2; Estrogen-related receptor beta; ERR-beta; Nuclear receptor subfamily 3 group B member 2 |
Protein Family: | Steroid hormone receptor |
UniProt Gene Name: | ESRRB |
UniProt Entry Name: | ERR2_HUMAN |