DYRK2 Antibody (PACO43181)
- SKU:
- PACO43181
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | DYRK2 Antibody (PACO43181) |
抗体コード: | PACO43181 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 2 protein (502-601AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43181 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43181 at dilution of 1:100. |
バックグラウンド: | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). |
シノニム: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1), DYRK2 |
UniProt Protein Function: | DYRK2: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3. |
UniProt Protein Details: | Protein type:Protein kinase, CMGC; Kinase, protein; Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; CMGC group; DYRK family; Dyrk2 subfamily Chromosomal Location of Human Ortholog: 12q15 Cellular Component: nucleoplasm; cytoplasm; nucleus; ribonucleoprotein complex; ubiquitin ligase complex Molecular Function:protein serine/threonine kinase activity; ubiquitin binding; protein binding; protein-tyrosine kinase activity; manganese ion binding; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding Biological Process: smoothened signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of glycogen biosynthetic process; negative regulation of NFAT protein import into nucleus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein amino acid phosphorylation; response to DNA damage stimulus |
NCBI Summary: | DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92630 |
NCBI GenInfo Identifier: | 148887370 |
NCBI Gene ID: | 8445 |
NCBI Accession: | Q92630.3 |
UniProt Secondary Accession: | Q92630,Q9BRB5, B2R9V9, |
UniProt Related Accession: | Q92630 |
Molecular Weight: | 601 |
NCBI Full Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
NCBI Synonym Full Names: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
NCBI Official Symbol: | DYRK2 |
NCBI Protein Information: | dual specificity tyrosine-phosphorylation-regulated kinase 2 |
UniProt Protein Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
Protein Family: | Dual specificity tyrosine-phosphorylation-regulated kinase |
UniProt Gene Name: | DYRK2 |
UniProt Entry Name: | DYRK2_HUMAN |
Antibodies |
Anti-DYRK2 Antibody (CAB7012) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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