DTX3 Antibody (PACO14338)
- SKU:
- PACO14338
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DTX3 Antibody (PACO14338) |
抗体コード: | PACO14338 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human DTX3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: PACO14338(DTX3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. |
バックグラウンド: | DTX3 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context By similarity. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
シノニム: | Deltex homolog 3 (Drosophila) |
UniProt Protein Function: | DTX3: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-Chromosomal Location of Human Ortholog: 12q13.3Molecular Function: protein binding |
UniProt Protein Details: | |
NCBI Summary: | DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
UniProt Code: | Q8N9I9 |
NCBI GenInfo Identifier: | 37077338 |
NCBI Gene ID: | 196403 |
NCBI Accession: | Q8N9I9.2 |
UniProt Secondary Accession: | Q8N9I9,Q53ZZ2, Q8NAU6, Q8NDS8 |
UniProt Related Accession: | Q8N9I9 |
Molecular Weight: | 38,155 Da |
NCBI Full Name: | Probable E3 ubiquitin-protein ligase DTX3 |
NCBI Synonym Full Names: | deltex E3 ubiquitin ligase 3 |
NCBI Official Symbol: | DTX3 |
NCBI Official Synonym Symbols: | RNF154; deltex3 |
NCBI Protein Information: | probable E3 ubiquitin-protein ligase DTX3 |
UniProt Protein Name: | Probable E3 ubiquitin-protein ligase DTX3 |
UniProt Synonym Protein Names: | Protein deltex-3; Deltex3; RING finger protein 154 |
Protein Family: | Protein DETOXIFICATION |
UniProt Gene Name: | DTX3 |
UniProt Entry Name: | DTX3_HUMAN |