| UniProt Protein Function: | CYP3A43: Exhibits low testosterone 6-beta-hydroxylase activity. Belongs to the cytochrome P450 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: endoplasmic reticulum membrane Molecular Function:monooxygenase activity |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9HB55 |
| NCBI GenInfo Identifier: | 20137481 |
| NCBI Gene ID: | 64816 |
| NCBI Accession: | Q9HB55.1 |
| UniProt Secondary Accession: | Q9HB55,Q495Y1, Q75MK2, Q75MK3, Q9HB52, Q9HB53, Q9HB54 Q9HB57, |
| UniProt Related Accession: | Q9HB55 |
| Molecular Weight: | 44,808 Da |
| NCBI Full Name: | Cytochrome P450 3A43 |
| NCBI Synonym Full Names: | cytochrome P450 family 3 subfamily A member 43 |
| NCBI Official Symbol: | CYP3A43 |
| NCBI Protein Information: | cytochrome P450 3A43 |
| UniProt Protein Name: | Cytochrome P450 3A43 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP3A43 |
| UniProt Entry Name: | CP343_HUMAN |
