CTCFL Antibody (PACO43180)
- SKU:
- PACO43180
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CTCFL Antibody (PACO43180) |
抗体コード: | PACO43180 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Transcriptional repressor CTCFL protein (1-270AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43180 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO43180 at dilution of 1:100. |
バックグラウンド: | Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. |
シノニム: | Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T), CTCFL, BORIS |
UniProt Protein Function: | BORIS: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. Testis specific. Specifically expressed in primary spermatocytes. Belongs to the CTCF zinc-finger protein family. |
UniProt Protein Details: | Protein type:DNA-binding; Cancer Testis Antigen (CTA); C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 20q13.31 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; DNA binding; histone binding; sequence-specific DNA binding; metal ion binding Biological Process: histone methylation; genetic imprinting; transcription, DNA-dependent; DNA methylation during gametogenesis; positive regulation of transcription, DNA-dependent; regulation of histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; cell cycle |
UniProt Code: | Q8NI51 |
NCBI GenInfo Identifier: | 313104098 |
NCBI Gene ID: | |
NCBI Accession: | Q8NI51.2 |
Molecular Weight: | |
NCBI Full Name: | Transcriptional repressor CTCFL |
UniProt Protein Name: | Transcriptional repressor CTCFL |
UniProt Synonym Protein Names: | Brother of the regulator of imprinted sites; CCCTC-binding factor; CTCF paralog; CTCF-like protein; Cancer/testis antigen 27; CT27; Zinc finger protein CTCF-T |
Protein Family: | Transcriptional repressor |
UniProt Gene Name: | CTCFL |
UniProt Entry Name: | CTCFL_HUMAN |
Antibodies | ELISA Kits |
Anti-CTCFL Antibody (CAB6149) | Human CTCFL ELISA Kit |
Human Transcriptional repressor CTCFL (CTCFL) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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