Description
| 抗体名: | CETN2 Antibody (PACO43188) |
| 抗体コード: | PACO43188 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Centrin-2 protein (1-172AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO43188 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43188 at dilution of 1:100. |
| バックグラウンド: | Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. |
| シノニム: | Centrin-2 (Caltractin isoform 1), CETN2, CALT CEN2 |
| UniProt Protein Function: | CETN2: a calcium-binding proteins and is a structural component of the centrosome. Contains 4 EF-hand calcium-binding domains. Highly conserved from algae to humans. Its association with the centrosome suggests that it plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. |
| UniProt Protein Details: | Protein type:DNA repair, damage; Calcium-binding; Cell cycle regulation Chromosomal Location of Human Ortholog: Xq28 Cellular Component: centriole; centrosome; intracellular; cytosol; photoreceptor connecting cilium Molecular Function:protein binding; microtubule binding; G-protein beta/gamma-subunit binding; calcium ion binding; heterotrimeric G-protein binding Biological Process: mitosis; cell division; nucleotide-excision repair; organelle organization and biogenesis; centriole replication; spermatogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; regulation of cytokinesis |
| NCBI Summary: | Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41208 |
| NCBI GenInfo Identifier: | 729052 |
| NCBI Gene ID: | 1069 |
| NCBI Accession: | P41208.1 |
| UniProt Secondary Accession: | P41208,Q53XW1, B2R4T4, |
| UniProt Related Accession: | P41208 |
| Molecular Weight: | 172 |
| NCBI Full Name: | Centrin-2 |
| NCBI Synonym Full Names: | centrin, EF-hand protein, 2 |
| NCBI Official Symbol: | CETN2 |
| NCBI Official Synonym Symbols: | CALT; CEN2 |
| NCBI Protein Information: | centrin-2; caltractin (20kD calcium-binding protein) |
| UniProt Protein Name: | Centrin-2 |
| UniProt Synonym Protein Names: | Caltractin isoform 1 |
| Protein Family: | Centrin |
| UniProt Gene Name: | CETN2 |
| UniProt Entry Name: | CETN2_HUMAN |
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