| UniProt Protein Function: | BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. |
| UniProt Protein Details: | Protein type:Cell surface; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: integral to plasma membrane Molecular Function:lipopolysaccharide binding Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production |
| NCBI Summary: | This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P17213 |
| NCBI GenInfo Identifier: | 215274242 |
| NCBI Gene ID: | 671 |
| NCBI Accession: | P17213.4 |
| UniProt Secondary Accession: | P17213,Q1ZZU8, Q5JRW0, Q8IW58, Q9BYZ9, Q9H1L2, Q9H1M8 Q9H203, Q9UCT4, Q9UD65, B2RCY2, |
| UniProt Related Accession: | P17213 |
| Molecular Weight: | |
| NCBI Full Name: | Bactericidal permeability-increasing protein |
| NCBI Synonym Full Names: | bactericidal/permeability-increasing protein |
| NCBI Official Symbol: | BPI |
| NCBI Official Synonym Symbols: | rBPI; BPIFD1 |
| NCBI Protein Information: | bactericidal permeability-increasing protein |
| UniProt Protein Name: | Bactericidal permeability-increasing protein |
| UniProt Synonym Protein Names: | CAP 57 |
| Protein Family: | BPI fold-containing family |
| UniProt Gene Name: | BPI |
| UniProt Entry Name: | BPI_HUMAN |
