Description
| 抗体名: | ATG10 Antibody (PACO43416) |
| 抗体コード: | PACO43416 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Ubiquitin-like-conjugating enzyme ATG10 protein (1-220AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43416 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon tissue using PACO43416 at dilution of 1:100. |
| バックグラウンド: | E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. |
| シノニム: | Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like), ATG10, APG10L |
| UniProt Protein Function: | ATG10: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Belongs to the ATG10 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Autophagy; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: cytosol; intracellular Molecular Function:APG12 conjugating enzyme activity Biological Process: autophagy; macroautophagy; positive regulation of protein modification process; protein amino acid lipidation; protein modification by small protein conjugation |
| NCBI Summary: | Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9H0Y0 |
| NCBI GenInfo Identifier: | 62286633 |
| NCBI Gene ID: | 83734 |
| NCBI Accession: | Q9H0Y0.1 |
| UniProt Secondary Accession: | Q9H0Y0,Q6PIX1, Q9H842, B2RE09, |
| UniProt Related Accession: | Q9H0Y0 |
| Molecular Weight: | 14,217 Da |
| NCBI Full Name: | Ubiquitin-like-conjugating enzyme ATG10 |
| NCBI Synonym Full Names: | autophagy related 10 |
| NCBI Official Symbol: | ATG10 |
| NCBI Official Synonym Symbols: | APG10; APG10L; pp12616 |
| NCBI Protein Information: | ubiquitin-like-conjugating enzyme ATG10 |
| UniProt Protein Name: | Ubiquitin-like-conjugating enzyme ATG10 |
| UniProt Synonym Protein Names: | Autophagy-related protein 10; APG10-like |
| Protein Family: | Ubiquitin-like-conjugating enzyme |
| UniProt Gene Name: | ATG10 |
| UniProt Entry Name: | ATG10_HUMAN |
