ATG10 Antibody (PACO15467)
- SKU:
- PACO15467
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ATG10 Antibody (PACO15467) |
抗体コード: | PACO15467 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human ATG10 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Mouse liver tissue, Primary antibody: PACO15467(ATG10 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15467(ATG10 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form. |
シノニム: | autophagy related 10 |
UniProt Protein Function: | ATG10: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Belongs to the ATG10 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; Autophagy; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: cytosol; intracellular Molecular Function:APG12 conjugating enzyme activity Biological Process: autophagy; macroautophagy; positive regulation of protein modification process; protein amino acid lipidation; protein modification by small protein conjugation |
NCBI Summary: | Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9H0Y0 |
NCBI GenInfo Identifier: | 62286633 |
NCBI Gene ID: | 83734 |
NCBI Accession: | Q9H0Y0.1 |
UniProt Secondary Accession: | Q9H0Y0,Q6PIX1, Q9H842, B2RE09, |
UniProt Related Accession: | Q9H0Y0 |
Molecular Weight: | 14,217 Da |
NCBI Full Name: | Ubiquitin-like-conjugating enzyme ATG10 |
NCBI Synonym Full Names: | autophagy related 10 |
NCBI Official Symbol: | ATG10 |
NCBI Official Synonym Symbols: | APG10; APG10L; pp12616 |
NCBI Protein Information: | ubiquitin-like-conjugating enzyme ATG10 |
UniProt Protein Name: | Ubiquitin-like-conjugating enzyme ATG10 |
UniProt Synonym Protein Names: | Autophagy-related protein 10; APG10-like |
Protein Family: | Ubiquitin-like-conjugating enzyme |
UniProt Gene Name: | ATG10 |
UniProt Entry Name: | ATG10_HUMAN |