Anti-SIGLEC10 Antibody (CAB20413)
- SKU:
- CAB20413
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- SLG2
- Synonyms:
- PRO940
- Synonyms:
- SIGLEC-10
Frequently bought together:
Description
| 抗体名: | SIGLEC10 Rabbit pAb |
| 抗体コード: | CAB20413 |
| サイズ: | 50uL, 100uL |
| 同義語: | SLG2, PRO940, SIGLEC-10 |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SIGLEC10. |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | Raji, Rat lung |
| 免疫原: | Recombinant protein of human SIGLEC10. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 89790 |
| Uniprot: | Q96LC7 |
| 計算された分子量: | 76kDa |
| 観察された分子量: | 100KDa |
| UniProt Protein Function: | Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 |
| NCBI Summary: | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] |
| UniProt Code: | Q96LC7 |
| NCBI GenInfo Identifier: | 118572721 |
| NCBI Gene ID: | 89790 |
| NCBI Accession: | Q96LC7.3 |
| UniProt Secondary Accession: | Q96LC7,Q3MIR5, Q6UXI8, Q96G54, Q96LC8, A8K1I5, A8K3C7 C9JJ33, C9JM10, F8W917, |
| UniProt Related Accession: | Q96LC7 |
| Molecular Weight: | 57,486 Da |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 10 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 10 |
| NCBI Official Symbol: | SIGLEC10 |
| NCBI Official Synonym Symbols: | SLG2; PRO940; SIGLEC-10 |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 10 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 10 |
| UniProt Synonym Protein Names: | Siglec-like protein 2 |
| Protein Family: | Sialic acid-binding Ig-like lectin |
| UniProt Gene Name: | SIGLEC10 |
| UniProt Entry Name: | SIG10_HUMAN |
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