Anti-PYCARD Antibody (CAB20484)

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SKU:
CAB20484
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
A
Synonyms:
Asc
Synonyms:
TMS-
Synonyms:
TNS1
Synonyms:
masc
Synonyms:
CARD5
Synonyms:
TMS-1
Synonyms:
9130417A21Rik
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Description

抗体名:PYCARD Rabbit pAb
抗体コード:CAB20484
サイズ:50uL, 100uL
同義語:A, Asc, TMS-, TNS1, masc, CARD5, TMS-1, 9130417A21Rik
申し込み:WB, IHC
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of Mouse PYCARD.
申し込み:WB, IHC
推奨される希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:THP-1, U-937, Mouse spleen, Mouse thymus, Rat spleen, Rat thymus
免疫原:Recombinant protein of Mouse PYCARD.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:66824
Uniprot:Q9EPB4
計算された分子量:21kDa
観察された分子量:25kDa
UniProt Protein Function:Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590).
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9EPB4
NCBI GenInfo Identifier:165377185
NCBI Gene ID:66824
NCBI Accession:NP_075747.3
UniProt Secondary Accession:Q9EPB4,Q9D2W9
UniProt Related Accession:Q9EPB4
Molecular Weight:28.9 kDa
NCBI Full Name:apoptosis-associated speck-like protein containing a CARD
NCBI Synonym Full Names:PYD and CARD domain containing
NCBI Official Symbol:Pycard  
NCBI Official Synonym Symbols:Asc; TNS1; masc; CARD5; TMS-1; 9130417A21Rik  
NCBI Protein Information:apoptosis-associated speck-like protein containing a CARD
UniProt Protein Name:Apoptosis-associated speck-like protein containing a CARD
UniProt Synonym Protein Names:PYD and CARD domain-containing protein
Protein Family:Apoptosis-associated speck-like protein
UniProt Gene Name:Pycard  
UniProt Entry Name:
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