Anti-PMEL Antibody (CAB5384)

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SKU:
CAB5384
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PMEL
Synonyms:
D12S53E
Synonyms:
ME20
Synonyms:
ME20-M
Synonyms:
ME20M
Synonyms:
P1
Synonyms:
P100
Synonyms:
PMEL17
Synonyms:
SI
Synonyms:
SIL
Synonyms:
SILV
Synonyms:
gp100
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Description

抗体名:PMEL Rabbit pAb
抗体コード:CAB5384
サイズ:20uL, 50uL, 100uL
同義語:PMEL, D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1).
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:A375
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:KVPR NQDW LGVS RQLR TKAW NRQL YPEW TEAQ RLDC WRGG QVSL KVSN DGPT LIGA NASF SIAL NFPG SQKV LPDG QVIW VNNT IING SQVW GGQP VYPQ ETDD ACIF PDGG PCPS GSWS QKRS FVYV WKTW GQYW QVLG GPVS GLSI GTGR AMLG THTM EVTV YHRR GSRS YVPL AHSS SAFT ITDQ VPFS VSVS QLRA LDGG NKHF LRNQ PLTF ALQL HDPS GYLA EADL SYTW DFGD SSGT LISR ALVV THTY LEPG PVTA QVVL QAAI PLTS
遺伝子ID:6490
Uniprot:P40967
セルラーロケーション:Endoplasmic reticulum membrane, Endosome, Golgi apparatus, Melanosome, Secreted, Single-pass type I membrane protein, multivesicular body
計算された分子量:60kDa/66kDa/70kDa
観察された分子量:80KDa/105KDa
UniProt Protein Function:SILV: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; melanosome; plasma membrane; extracellular region; integral to membrane

Molecular Function:protein binding

Biological Process: melanin biosynthetic process; melanosome organization and biogenesis

NCBI Summary:This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
UniProt Code:P40967
NCBI GenInfo Identifier:2507099
NCBI Gene ID:6490
NCBI Accession:P40967.2
UniProt Secondary Accession:P40967,Q12763, Q14448, Q14817, Q16565, B3KS57, B7Z6D7
UniProt Related Accession:P40967
Molecular Weight:70,255 Da
NCBI Full Name:Melanocyte protein PMEL
NCBI Synonym Full Names:premelanosome protein
NCBI Official Symbol:PMEL  
NCBI Official Synonym Symbols:P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E  
NCBI Protein Information:melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100
UniProt Protein Name:Melanocyte protein PMEL
UniProt Synonym Protein Names:ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homologCleaved into the following 2 chains:M-alpha; Alternative name(s):; 95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen
UniProt Gene Name:PMEL  
UniProt Entry Name:PMEL_HUMAN
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