Anti-Phospho-MLKL-S358 Antibody (CABP1244)
- SKU:
- CABP1244
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MLKL
- Synonyms:
- hMLKL
- Synonyms:
- mixed lineage kinase domain-like protein
Frequently bought together:
Description
| 抗体名: | Phospho-MLKL-S358 Rabbit pAb |
| 抗体コード: | CABP1244 |
| サイズ: | 50uL, 100uL |
| 同義語: | MLKL, hMLKL, mixed lineage kinase domain-like protein |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho synthetic peptide corresponding to residues surrounding S358 of human MLKL. |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | C6 |
| 免疫原: | A phospho synthetic peptide corresponding to residues surrounding S358 of human MLKL. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 197259 |
| Uniprot: | Q8NB16 |
| セルラーロケーション: | Cell membrane, Cytoplasm |
| 計算された分子量: | 53kDa/54kDa |
| 観察された分子量: | 54KDa |
| UniProt Protein Function: | MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; TKL-Unique family Chromosomal Location of Human Ortholog: 16q23.1 Cellular Component: cytoplasm; cytosol; plasma membrane Molecular Function:ATP binding; protein binding; protein complex binding; protein kinase activity; signal transducer activity Biological Process: protein amino acid phosphorylation |
| NCBI Summary: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q8NB16 |
| NCBI GenInfo Identifier: | 74762545 |
| NCBI Gene ID: | 197259 |
| NCBI Accession: | Q8NB16.1 |
| UniProt Secondary Accession: | Q8NB16,Q8N6V0, A6NCE4, |
| UniProt Related Accession: | Q8NB16 |
| Molecular Weight: | 54kDa |
| NCBI Full Name: | Mixed lineage kinase domain-like protein |
| NCBI Synonym Full Names: | mixed lineage kinase domain like pseudokinase |
| NCBI Official Symbol: | MLKL |
| NCBI Official Synonym Symbols: | hMLKL |
| NCBI Protein Information: | mixed lineage kinase domain-like protein |
| UniProt Protein Name: | Mixed lineage kinase domain-like protein |
| UniProt Gene Name: | MLKL |
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