Anti-CD274 Antibody (CAB20481)
- SKU:
- CAB20481
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PD-
- Synonyms:
- B7h1
- Synonyms:
- Pdl1
- Synonyms:
- Pdcd1l
- Synonyms:
- Pdcd1l1
- Synonyms:
- Pdcd1lg1
- Synonyms:
- A530045L16Rik
Frequently bought together:
Description
| I抗体名: | CD274 Rabbit pAb |
| 抗体コード: | CAB20481 |
| サイズ: | 50uL, 100uL |
| 同義語: | PD-, B7h1, Pdl1, Pdcd1l, Pdcd1l1, Pdcd1lg1, A530045L16Rik |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of Mouse CD274. |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, Mouse skeletal muscle, Rat skeletal muscle |
| 免疫原: | Recombinant protein of Mouse CD274. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 60533 |
| Uniprot: | Q9EP73 |
| 計算された分子量: | 32kDa |
| 観察された分子量: | 40-50KDa |
| UniProt Protein Function: | Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| NCBI Summary: | The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9EP73 |
| NCBI GenInfo Identifier: | 83287885 |
| NCBI Gene ID: | 60533 |
| NCBI Accession: | Q9EP73.1 |
| UniProt Related Accession: | Q9EP73 |
| Molecular Weight: | 32,780 Da |
| NCBI Full Name: | Programmed cell death 1 ligand 1 |
| NCBI Synonym Full Names: | CD274 antigen |
| NCBI Official Symbol: | Cd274 |
| NCBI Official Synonym Symbols: | B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik |
| NCBI Protein Information: | programmed cell death 1 ligand 1 |
| UniProt Protein Name: | Programmed cell death 1 ligand 1 |
| UniProt Synonym Protein Names: | B7 homolog 1; B7-H1; CD_antigen: CD274 |
| Protein Family: | Programmed cell death |
| UniProt Gene Name: | Cd274 |
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