Anti-ANK3 Antibody (CAB20299)

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SKU:
CAB20299
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MRT37
Synonyms:
ANKYRIN-G
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Description

抗体名:ANK3 Rabbit pAb
抗体コード:CAB20299
サイズ:50uL, 100uL
同義語:MRT37, ANKYRIN-G
申し込み:WB, IF
反応性:Human
宿主種:Rabbit
免疫原:Recombinant protein of human ANK3.
申し込み:WB, IF
推奨される希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human
免疫原:Recombinant protein of human ANK3.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:288
Uniprot:Q12955
計算された分子量:480kDa
観察された分子量:Refer to figures
UniProt Protein Function:ANK3: In skeletal muscle, required for costamere localization of DMD and betaDAG1. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 10q21 Cellular Component: Golgi apparatus; tight junction; cell surface; costamere; sarcoplasmic reticulum; basolateral plasma membrane; endoplasmic reticulum; lysosome; T-tubule; paranode region of axon; dendrite; Z disc; postsynaptic membrane; plasma membrane; basal plasma membrane; neuromuscular junction; sarcolemma; lateral plasma membrane Molecular Function: protein binding, bridging; protein binding; spectrin binding; structural constituent of cytoskeleton; cadherin binding; cytoskeletal protein binding Biological Process: axon guidance; cytoskeletal anchoring; regulation of potassium ion transport; generation of action potential; signal transduction; positive regulation of homotypic cell-cell adhesion; establishment of protein localization; plasma membrane organization and biogenesis; axonogenesis; cytokinesis after mitosis; Golgi to plasma membrane protein transport; positive regulation of membrane potential; neuromuscular junction development Disease: Mental Retardation, Autosomal Recessive 37
UniProt Protein Details:
NCBI Summary:Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
UniProt Code:Q12955
NCBI GenInfo Identifier:32967601
NCBI Gene ID:288
NCBI Accession:NP_066267.2
UniProt Secondary Accession:Q12955,Q13484, Q5CZH9, Q5VXD5, Q7Z3G4, Q9H0P5, B1AQT2 B4DIL1, E9PE32
UniProt Related Accession:Q12955
Molecular Weight:160,947 Da
NCBI Full Name:ankyrin-3 isoform 1
NCBI Synonym Full Names:ankyrin 3, node of Ranvier (ankyrin G)
NCBI Official Symbol:ANK3  
NCBI Official Synonym Symbols:MRT37; ANKYRIN-G  
NCBI Protein Information:ankyrin-3; ankyrin G119
UniProt Protein Name:Ankyrin-3
UniProt Synonym Protein Names:Ankyrin-G
Protein Family:Ankyrin
UniProt Gene Name:ANK3  
UniProt Entry Name:ANK3_HUMAN
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