Anti-ACSL4 Antibody (CAB20414)

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SKU:
CAB20414
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ACSL4
Synonyms:
ACS4
Synonyms:
FACL4
Synonyms:
LACS4
Synonyms:
MRX63
Synonyms:
MRX68
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Description

抗体名:ACSL4 Rabbit mAb
抗体コード:CAB20414
サイズ:50uL, 100uL
同義語:ACSL4, ACS4, FACL4, LACS4, MRX63, MRX68
申し込み:WB, IP
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthetic peptide of human ACSL4.
申し込み:WB, IP
推奨される希釈:WB 1:500 - 1:2000 IP 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, HepG2, Mouse liver, Rat liver
免疫原:A synthetic peptide of human ACSL4.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:KLER FEIP IKVR LS
遺伝子ID:2182
Uniprot:O60488
セルラーロケーション:Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion outer membrane, Peroxisome membrane, Single-pass type III membrane protein
計算された分子量:74kDa/79kDa
観察された分子量:79kDa
UniProt Protein Function:ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - fatty acid; Membrane protein, integral; EC 6.2.1.3; Ligase

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane

Molecular Function:arachidonate-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: lipid metabolic process

Disease: Mental Retardation, X-linked 63

NCBI Summary:The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Code:O60488
NCBI GenInfo Identifier:13432172
NCBI Gene ID:2182
NCBI Accession:O60488.2
UniProt Secondary Accession:O60488,O60848, O60849, Q5JWV8, D3DUY2,
UniProt Related Accession:O60488
Molecular Weight:74,436 Da
NCBI Full Name:Long-chain-fatty-acid--CoA ligase 4
NCBI Synonym Full Names:acyl-CoA synthetase long-chain family member 4
NCBI Official Symbol:ACSL4  
NCBI Official Synonym Symbols:ACS4; FACL4; LACS4; MRX63; MRX68  
NCBI Protein Information:long-chain-fatty-acid--CoA ligase 4
UniProt Protein Name:Long-chain-fatty-acid--CoA ligase 4
UniProt Synonym Protein Names:Long-chain acyl-CoA synthetase 4; LACS 4
UniProt Gene Name:ACSL4  
UniProt Entry Name:ACSL4_HUMAN
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