Description
| 抗体名: | AIM2 Antibody (PACO07658) |
| 抗体コード: | PACO07658 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Human AIM2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | absent in melanoma 2;AIM2;PYHIN4 ; |
| UniProt Protein Function: | AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 1q22 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:identical protein binding; protein binding; double-stranded DNA binding Biological Process: positive regulation of interleukin-1 beta production; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway; apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; immune response; positive regulation of interleukin-1 beta secretion; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response; activation of NF-kappaB transcription factor |
| NCBI Summary: | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14862 |
| NCBI GenInfo Identifier: | 5902751 |
| NCBI Gene ID: | 9447 |
| NCBI Accession: | O14862.1 |
| UniProt Secondary Accession: | O14862,Q5T3V9, Q96FG9, A8K7M7, |
| UniProt Related Accession: | O14862 |
| Molecular Weight: | 343 |
| NCBI Full Name: | Interferon-inducible protein AIM2 |
| NCBI Synonym Full Names: | absent in melanoma 2 |
| NCBI Official Symbol: | AIM2 |
| NCBI Official Synonym Symbols: | PYHIN4 |
| NCBI Protein Information: | interferon-inducible protein AIM2 |
| UniProt Protein Name: | Interferon-inducible protein AIM2 |
| UniProt Synonym Protein Names: | Absent in melanoma 2 |
| Protein Family: | Protein |
| UniProt Gene Name: | AIM2 |
| UniProt Entry Name: | AIM2_HUMAN |
