| UniProt Protein Function: | ZWINT: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 10q21-q22 Cellular Component: cytoplasm; cytosol; kinetochore Molecular Function:protein binding; protein N-terminus binding Biological Process: establishment of cellular localization; mitotic cell cycle checkpoint; mitotic sister chromatid segregation; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95229 |
| NCBI GenInfo Identifier: | 117949386 |
| NCBI Gene ID: | 11130 |
| NCBI Accession: | O95229.2 |
| UniProt Secondary Accession: | O95229,Q0D2I3, Q9BWD0, A6NNV6, |
| UniProt Related Accession: | O95229 |
| Molecular Weight: | 25,544 Da |
| NCBI Full Name: | ZW10 interactor |
| NCBI Synonym Full Names: | ZW10 interacting kinetochore protein |
| NCBI Official Symbol: | ZWINT |
| NCBI Official Synonym Symbols: | SIP30; ZWINT1; KNTC2AP; HZwint-1 |
| NCBI Protein Information: | ZW10 interactor |
| UniProt Protein Name: | ZW10 interactor |
| UniProt Synonym Protein Names: | ZW10-interacting protein 1; Zwint-1 |
| Protein Family: | ZW10 interactor |
| UniProt Gene Name: | ZWINT |
| UniProt Entry Name: | ZWINT_HUMAN |
