Description
| 抗体名: | YTHDC1 Antibody, HRP conjugated (PACO48063) |
| 抗体コード: | PACO48063 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human YTH domain-containing protein 1 protein (89-153AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May also regulate alternative splice site selection. |
| シノニム: | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B), YTHDC1, KIAA1966 YT521 |
| UniProt Protein Function: | YT521: May be part of a signal transduction pathway that influences splice site selection. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 4q13.2 Cellular Component: nuclear body; nucleus Molecular Function:protein binding; RNA binding Biological Process: mRNA splice site selection |
| UniProt Code: | Q96MU7 |
| NCBI GenInfo Identifier: | 47606762 |
| NCBI Gene ID: | 91746 |
| NCBI Accession: | Q96MU7.3 |
| UniProt Secondary Accession: | Q96MU7,Q4W5Q3, Q7Z622, Q8TF35, |
| UniProt Related Accession: | Q96MU7 |
| Molecular Weight: | 727 |
| NCBI Full Name: | YTH domain-containing protein 1 |
| NCBI Synonym Full Names: | YTH domain containing 1 |
| NCBI Official Symbol: | YTHDC1 |
| NCBI Official Synonym Symbols: | YT521; YT521-B |
| NCBI Protein Information: | YTH domain-containing protein 1; splicing factor YT521-B; putative splicing factor YT521 |
| UniProt Protein Name: | YTH domain-containing protein 1 |
| UniProt Synonym Protein Names: | Putative splicing factor YT521; YT521-B |
| Protein Family: | YTH domain-containing protein |
| UniProt Gene Name: | YTHDC1 |
| UniProt Entry Name: | YTDC1_HUMAN |
