Description
| 抗体名: | XRN2 Antibody |
| 抗体コード: | PACO03285 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Monkey |
| 免疫原: | synthesized peptide derived from the N-terminal region of human XRN2. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | XRN2; 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein |
| UniProt Protein Function: | XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Ribonuclease; Nucleolus; EC 3.1.13.-; RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 20p11.2-p11.1 Cellular Component: membrane; nucleolus; nucleus Molecular Function:5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; protein binding; zinc ion binding Biological Process: cell growth; DNA catabolic process, exonucleolytic; mRNA processing; regulation of transcription, DNA-dependent; RNA catabolic process; RNA metabolic process; RNA processing; spermatogenesis; transcription termination |
| NCBI Summary: | This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9H0D6 |
| NCBI GenInfo Identifier: | 30173484 |
| NCBI Gene ID: | 22803 |
| NCBI Accession: | Q9H0D6.1 |
| UniProt Secondary Accession: | Q9H0D6,Q3L8N4, Q6KGZ9, Q9BQL1, Q9NTW0, Q9NXS6, Q9UL53 |
| UniProt Related Accession: | Q9H0D6 |
| Molecular Weight: | 99,962 Da |
| NCBI Full Name: | 5'-3' exoribonuclease 2 |
| NCBI Synonym Full Names: | 5'-3' exoribonuclease 2 |
| NCBI Official Symbol: | XRN2 |
| NCBI Protein Information: | 5'-3' exoribonuclease 2 |
| UniProt Protein Name: | 5'-3' exoribonuclease 2 |
| UniProt Synonym Protein Names: | DHM1-like protein; DHP protein |
| UniProt Gene Name: | XRN2 |
| UniProt Entry Name: | XRN2_HUMAN |
