Description
| 抗体名: | WAC Antibody, Biotin conjugated (PACO47025) |
| 抗体コード: | PACO47025 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid, starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. |
| シノニム: | WW domain-containing adapter protein with coiled-coil, WAC, KIAA1844 |
| UniProt Protein Function: | WAC: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10p12.1|10p12.1-p11.2 Cellular Component: nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding Biological Process: histone monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macroautophagy; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus |
| NCBI Summary: | The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9BTA9 |
| NCBI GenInfo Identifier: | 117949358 |
| NCBI Gene ID: | 51322 |
| NCBI Accession: | Q9BTA9.3 |
| UniProt Secondary Accession: | Q9BTA9,Q53EN9, Q5JU75, Q5JU77, Q5VXK0, Q5VXK2, Q8TCK1 A8K2A9, C9JBT9, D3DRW5, D3DRW6, D3DRW7, |
| UniProt Related Accession: | Q9BTA9 |
| Molecular Weight: | 59,505 Da |
| NCBI Full Name: | WW domain-containing adapter protein with coiled-coil |
| NCBI Synonym Full Names: | WW domain containing adaptor with coiled-coil |
| NCBI Official Symbol: | WAC |
| NCBI Official Synonym Symbols: | Wwp4; DESSH; BM-016; PRO1741 |
| NCBI Protein Information: | WW domain-containing adapter protein with coiled-coil |
| UniProt Protein Name: | WW domain-containing adapter protein with coiled-coil |
| Protein Family: | Fibritin |
| UniProt Gene Name: | WAC |
| UniProt Entry Name: | WAC_HUMAN |
