Description
| 抗体名: | VANGL2 Antibody (PACO44813) |
| 抗体コード: | PACO44813 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Vang-like protein 2 protein (1-110AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO44813 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO44813 at dilution of 1:100. |
| バックグラウンド: | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). |
| シノニム: | Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2), VANGL2, KIAA1215 STB1 |
| UniProt Protein Function: | VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis Disease: Neural Tube Defects |
| NCBI Summary: | The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9ULK5 |
| NCBI GenInfo Identifier: | 38258849 |
| NCBI Gene ID: | 57216 |
| NCBI Accession: | Q9ULK5.2 |
| UniProt Secondary Accession: | Q9ULK5,Q5T212, D3DVE9, |
| UniProt Related Accession: | Q9ULK5 |
| Molecular Weight: | 59,714 Da |
| NCBI Full Name: | Vang-like protein 2 |
| NCBI Synonym Full Names: | VANGL planar cell polarity protein 2 |
| NCBI Official Symbol: | VANGL2 |
| NCBI Official Synonym Symbols: | LPP1; LTAP; STB1; STBM; STBM1 |
| NCBI Protein Information: | vang-like protein 2 |
| UniProt Protein Name: | Vang-like protein 2 |
| UniProt Synonym Protein Names: | Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2 |
| Protein Family: | Vang-like protein |
| UniProt Gene Name: | VANGL2 |
| UniProt Entry Name: | VANG2_HUMAN |
| Antibodies |
| Anti-VANGL2 Antibody (CAB7825) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
