The UTP20 Polyclonal Antibody (PAC013147) is a valuable tool for researchers studying UTP20, a protein involved in RNA processing and ribosome biogenesis. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to UTP20, this antibody allows for the detection and analysis of the protein in different cell types, making it ideal for studies in molecular biology and gene expression research.UTP20 is a key player in the biogenesis of the small ribosomal subunit and is essential for proper RNA processing.
Dysregulation of UTP20 has been implicated in various diseases, including cancer and developmental disorders. Investigating the role of UTP20 in these conditions can provide valuable insights into disease mechanisms and potential therapeutic targets. The UTP20 Polyclonal Antibody is a reliable tool for researchers seeking to better understand the functions of UTP20 and its implications in disease pathology.
UTP20, small subunit (SSU) processome component, homolog (yeast);UTP20;DRIM ;
UniProt Protein Function:
DRIM: Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. Belongs to the UTP20 family.Protein type: Nucleolus; TranslationChromosomal Location of Human Ortholog: 12q23Cellular Component: cytoplasm; nucleolar preribosome, small subunit precursor; nucleolus; nucleoplasm; small subunit processomeMolecular Function: protein bindingBiological Process: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell proliferation; rRNA processing
UniProt Protein Details:
NCBI Summary:
UTP20 is a component of the U3 small nucleolar RNA (snoRNA) (SNORD3A; MIM 180710) protein complex (U3 snoRNP) and is involved in 18S rRNA processing (Wang et al., 2007 [PubMed 17498821]).[supplied by OMIM, Jun 2009]
