Description
| 抗体名: | USP13 Antibody (PACO13118) |
| 抗体コード: | PACO13118 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human USP13 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | ubiquitin specific peptidase 13 (isopeptidase T-3);USP13;ISOT3;IsoT-3 ; |
| UniProt Protein Function: | USP13: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: cytosol; nucleoplasm Molecular Function:chaperone binding; cysteine-type endopeptidase activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity Biological Process: cell proliferation; melanocyte differentiation; protein deubiquitination; protein stabilization; regulation of autophagy; regulation of transcription, DNA-dependent |
| UniProt Code: | Q92995 |
| NCBI GenInfo Identifier: | 209572692 |
| NCBI Gene ID: | 8975 |
| NCBI Accession: | Q92995.2 |
| UniProt Secondary Accession: | Q92995,Q96B25, A8K2S3, B4DYF3, D3DNS2, |
| UniProt Related Accession: | Q92995 |
| Molecular Weight: | 97kDa |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 13 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 13 (isopeptidase T-3) |
| NCBI Official Symbol: | USP13 |
| NCBI Official Synonym Symbols: | ISOT3; IsoT-3 |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 13 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 13 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 13; Isopeptidase T-3; ISOT-3; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13 |
| UniProt Gene Name: | USP13 |
