Description
| 抗体名: | ULK3 Antibody (PACO44712) |
| 抗体コード: | PACO44712 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Serine/threonine-protein kinase ULK3 protein (44-240AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO44712 at dilution of 1:100. |
| バックグラウンド: | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. |
| シノニム: | Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3), ULK3 |
| UniProt Protein Function: | ULK3: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; ULK family Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: cytoplasm Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: autophagy; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; protein amino acid autophosphorylation |
| UniProt Code: | Q6PHR2 |
| NCBI GenInfo Identifier: | 259016166 |
| NCBI Gene ID: | 25989 |
| NCBI Accession: | Q6PHR2.2 |
| UniProt Secondary Accession: | Q6PHR2,Q9NPN5, Q9UFS4, B2RXK3, B4DFT0, B4DRQ7, D3DW68 |
| UniProt Related Accession: | Q6PHR2 |
| Molecular Weight: | 54,997 Da |
| NCBI Full Name: | Serine/threonine-protein kinase ULK3 |
| NCBI Synonym Full Names: | unc-51 like kinase 3 |
| NCBI Official Symbol: | ULK3 |
| NCBI Protein Information: | serine/threonine-protein kinase ULK3 |
| UniProt Protein Name: | Serine/threonine-protein kinase ULK3 |
| UniProt Synonym Protein Names: | Unc-51-like kinase 3 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | ULK3 |
| UniProt Entry Name: | ULK3_HUMAN |
