Description
| 抗体名: | UBE2T Antibody |
| 抗体コード: | PACO01673 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Mouse |
| 免疫原: | synthesized peptide derived from the Internal region of human UBE2T. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | UBE2T; HSPC150; PIG50; Ubiquitin-conjugating enzyme E2 T; Cell proliferation-inducing gene 50 protein; Ubiquitin carrier protein T; Ubiquitin-protein ligase T |
| UniProt Protein Function: | UBE2T: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; chromatin binding; ATP binding; ligase activity Biological Process: protein monoubiquitination; protein autoubiquitination; DNA repair; response to DNA damage stimulus Disease: Fanconi Anemia, Complementation Group T |
| NCBI Summary: | The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NPD8 |
| NCBI GenInfo Identifier: | 73622065 |
| NCBI Gene ID: | 29089 |
| NCBI Accession: | Q9NPD8.1 |
| UniProt Secondary Accession: | Q9NPD8,Q2TU36, |
| UniProt Related Accession: | Q9NPD8 |
| Molecular Weight: | 197 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 T |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2T |
| NCBI Official Symbol: | UBE2T |
| NCBI Official Synonym Symbols: | PIG50; HSPC150 |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 T; ubiquitin-protein ligase T; ubiquitin carrier protein T; ubiquitin conjugating enzyme; cell proliferation-inducing gene 50 protein; ubiquitin-conjugating enzyme E2T (putative); HSPC150 protein similar to ubiquitin-conjugating enzyme |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 T |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 50 protein; Ubiquitin carrier protein T; Ubiquitin-protein ligase T |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2T |
| UniProt Entry Name: | UBE2T_HUMAN |
