Description
| 抗体名: | UBA2 Antibody |
| 抗体コード: | PACO01668 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human |
| 免疫原: | synthesized peptide derived from the C-terminal region of human UBA2. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | UBA2; SAE2; UBLE1B; HRIHFB2115; SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B |
| UniProt Protein Function: | SAE2: a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 19q12 Cellular Component: nucleoplasm; cytosol; nucleus Molecular Function:SUMO activating enzyme activity; protein binding; protein heterodimerization activity; metal ion binding; enzyme activator activity; transcription factor binding; ATP binding Biological Process: positive regulation of catalytic activity; cellular protein metabolic process; protein sumoylation; SMT3-dependent protein catabolic process; post-translational protein modification |
| NCBI Summary: | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
| UniProt Code: | Q9UBT2 |
| NCBI GenInfo Identifier: | 42559898 |
| NCBI Gene ID: | 10054 |
| NCBI Accession: | Q9UBT2.2 |
| UniProt Secondary Accession: | Q9UBT2,O95605, Q59H87, Q6IBP6, Q9NTJ1, Q9UED2, B3KWB9 |
| UniProt Related Accession: | Q9UBT2 |
| Molecular Weight: | 640 |
| NCBI Full Name: | SUMO-activating enzyme subunit 2 |
| NCBI Synonym Full Names: | ubiquitin-like modifier activating enzyme 2 |
| NCBI Official Symbol: | UBA2 |
| NCBI Official Synonym Symbols: | ARX; SAE2; HRIHFB2115 |
| NCBI Protein Information: | SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog |
| UniProt Protein Name: | SUMO-activating enzyme subunit 2 |
| UniProt Synonym Protein Names: | Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2 |
| Protein Family: | Ubiquitin-activating enzyme |
| UniProt Gene Name: | UBA2 |
| UniProt Entry Name: | SAE2_HUMAN |
