| UniProt Protein Function: | TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Oxidoreductase Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:FAD binding; protein binding; thioredoxin-disulfide reductase activity Biological Process: cell redox homeostasis; response to oxygen radical; response to reactive oxygen species |
| NCBI Summary: | This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9NNW7 |
| NCBI GenInfo Identifier: | 182705230 |
| NCBI Gene ID: | 10587 |
| NCBI Accession: | Q9NNW7.3 |
| UniProt Secondary Accession: | Q9NNW7,O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0 Q9P2Y1, Q9UQU8, |
| UniProt Related Accession: | Q9NNW7 |
| Molecular Weight: | 30,291 Da |
| NCBI Full Name: | Thioredoxin reductase 2, mitochondrial |
| NCBI Synonym Full Names: | thioredoxin reductase 2 |
| NCBI Official Symbol: | TXNRD2 |
| NCBI Official Synonym Symbols: | TR; TR3; SELZ; TRXR2; TR-BETA |
| NCBI Protein Information: | thioredoxin reductase 2, mitochondrial |
| UniProt Protein Name: | Thioredoxin reductase 2, mitochondrial |
| UniProt Synonym Protein Names: | Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3 |
| Protein Family: | Thioredoxin reductase |
| UniProt Gene Name: | TXNRD2 |
| UniProt Entry Name: | TRXR2_HUMAN |
