| UniProt Protein Function: | TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:protein binding; protein disulfide isomerase activity Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q8NBS9 |
| NCBI GenInfo Identifier: | 29839560 |
| NCBI Gene ID: | 81567 |
| NCBI Accession: | Q8NBS9.2 |
| UniProt Related Accession: | Q8NBS9 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin domain-containing protein 5 |
| NCBI Synonym Full Names: | thioredoxin domain containing 5 |
| NCBI Official Symbol: | TXNDC5 |
| NCBI Official Synonym Symbols: | HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI |
| NCBI Protein Information: | thioredoxin domain-containing protein 5 |
| UniProt Protein Name: | Thioredoxin domain-containing protein 5 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46 |
| UniProt Gene Name: | TXNDC5 |
| UniProt Entry Name: | TXND5_HUMAN |
![Anti-TXNDC5 Antibody (CAB19931)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/590x590/products/150740/150521/anti-txndc5-antibody-cab19931ko-validated__96720__23701.1750436199.jpg?c=1 "Anti-TXNDC5 Antibody (CAB19931)[KO Validated]")
![Anti-TXNDC5 Antibody (CAB19930)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/590x590/products/150739/150520/anti-txndc5-antibody-cab19930ko-validated__60524__62724.1750436199.jpg?c=1 "Anti-TXNDC5 Antibody (CAB19930)[KO Validated]")
