| UniProt Protein Function: | TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cell soma; mitochondrion; mitochondrial matrix; dendrite; nucleolus Molecular Function:peptide-methionine-(S)-S-oxide reductase activity; protein complex binding; protein disulfide oxidoreductase activity; peptide-methionine (R)-S-oxide reductase activity Biological Process: response to drug; cellular response to nutrient levels; response to reactive oxygen species; cell redox homeostasis; response to hormone stimulus; response to glucose stimulus; response to hypoxia; response to axon injury; response to organic cyclic substance; glycerol ether metabolic process; response to nutrient |
| NCBI Summary: | This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99757 |
| NCBI GenInfo Identifier: | 20455529 |
| NCBI Gene ID: | 25828 |
| NCBI Accession: | Q99757.2 |
| UniProt Secondary Accession: | Q99757,Q5JZA0, Q6FH60, Q9UH29, |
| UniProt Related Accession: | Q99757 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin, mitochondrial |
| NCBI Synonym Full Names: | thioredoxin 2 |
| NCBI Official Symbol: | TXN2 |
| NCBI Official Synonym Symbols: | MTRX; TRX2; MT-TRX |
| NCBI Protein Information: | thioredoxin, mitochondrial; thioredoxin-2; mitochondrial thioredoxin |
| UniProt Protein Name: | Thioredoxin, mitochondrial |
| UniProt Synonym Protein Names: | Thioredoxin-2 |
| UniProt Gene Name: | TXN2 |
| UniProt Entry Name: | THIOM_HUMAN |
