Description
TSPAN14 Antibody (PACO39462)
The TSPAN14 Monoclonal Antibody (PACO39462) is a valuable tool for researchers studying the TSPAN14 protein, a member of the tetraspanin family involved in various cellular processes. This antibody, generated in mice, exhibits high specificity and sensitivity for detecting TSPAN14 in human samples, making it suitable for use in Western blot and immunohistochemistry applications.TSPAN14 is known to play a role in cell adhesion, migration, and signal transduction, making it a key player in processes like tumorigenesis and metastasis.
Its overexpression has been linked to various cancers, making it a promising target for cancer research and therapy development. By using the TSPAN14 Monoclonal Antibody, researchers can further investigate the function and regulation of TSPAN14 in both normal and disease states, advancing our understanding of its potential as a therapeutic target.
| Antibody Name: | TSPAN14 Antibody (PACO39462) |
| Antibody SKU: | PACO39462 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Tetraspanin-14 protein (114-215AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of U251 cells using PACO39462 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39462 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO39462 at dilution of 1:100. |
| Background: | integral component of plasma membrane, plasma membrane, enzyme binding, establishment of protein localization to plasma membrane, positive regulation of Notch signaling pathway, protein maturation |
| Synonyms: | Tetraspanin-14 (Tspan-14) (DC-TM4F2) (Transmembrane 4 superfamily member 14), TSPAN14, TM4SF14 |
| UniProt Protein Function: | TSPAN14: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. 3 isoforms of the human protein are produced by alternative splicing. and RefSeq |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10q23.1 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:enzyme binding Biological Process: cell surface receptor linked signal transduction; positive regulation of Notch signaling pathway; protein maturation |
| UniProt Code: | Q8NG11 |
| NCBI GenInfo Identifier: | 190341022 |
| NCBI Gene ID: | 81619 |
| NCBI Accession: | NP_001121781.1 |
| UniProt Secondary Accession: | Q8NG11,Q567U7, Q9BU34, Q9H0U1, A6NHE1, B4DHY6, D3DWD7 D3DWD8, |
| UniProt Related Accession: | Q8NG11 |
| Molecular Weight: | |
| NCBI Full Name: | tetraspanin-14 isoform 2 |
| NCBI Synonym Full Names: | tetraspanin 14 |
| NCBI Official Symbol: | TSPAN14 |
| NCBI Official Synonym Symbols: | TM4SF14; DC-TM4F2 |
| NCBI Protein Information: | tetraspanin-14 |
| UniProt Protein Name: | Tetraspanin-14 |
| UniProt Synonym Protein Names: | DC-TM4F2; Transmembrane 4 superfamily member 14 |
| UniProt Gene Name: | TSPAN14 |
| UniProt Entry Name: | TSN14_HUMAN |
