Description
| 抗体名: | TSC2 Antibody, Biotin conjugated (PACO47857) |
| 抗体コード: | PACO47857 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Tuberin protein (1396-1496AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5. |
| シノニム: | Tuberin (Tuberous sclerosis 2 protein), TSC2, TSC4 |
| UniProt Protein Function: | TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; cytosol; Golgi apparatus; lysosome; membrane; nucleus; perinuclear region of cytoplasm; TSC1-TSC2 complex Molecular Function:GTPase activator activity; phosphatase binding; protein binding; protein homodimerization activity; small GTPase binding Biological Process: anoikis; cell cycle arrest; endocytosis; heart development; insulin-like growth factor receptor signaling pathway; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase activity; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of Wnt receptor signaling pathway; neural tube closure; positive chemotaxis; positive regulation of macroautophagy; protein import into nucleus; protein kinase B signaling cascade; protein localization; regulation of cell cycle; regulation of endocytosis; regulation of insulin receptor signaling pathway; vesicle-mediated transport Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 2 |
| NCBI Summary: | Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49815 |
| NCBI GenInfo Identifier: | 269849475 |
| NCBI Gene ID: | 7249 |
| NCBI Accession: | P49815.2 |
| UniProt Secondary Accession: | P49815,O75275, Q4LE71, Q8TAZ1, A7E2E2, B4DIL8, B4DIQ7 B4DRN2, B7Z2B8, C9J378, |
| UniProt Related Accession: | P49815 |
| Molecular Weight: | 25,773 Da |
| NCBI Full Name: | Tuberin |
| NCBI Synonym Full Names: | tuberous sclerosis 2 |
| NCBI Official Symbol: | TSC2 |
| NCBI Official Synonym Symbols: | LAM; TSC4; PPP1R160 |
| NCBI Protein Information: | tuberin |
| UniProt Protein Name: | Tuberin |
| UniProt Synonym Protein Names: | Tuberous sclerosis 2 protein |
| Protein Family: | Tuberin |
| UniProt Gene Name: | TSC2 |
