Description
| 抗体名: | TRPV2 Antibody (PACO57620) |
| 抗体コード: | PACO57620 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Transient receptor potential cation channel subfamily V member 2 protein (1-117AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse skeletal muscle tissue. All lanes: TRPV2 antibody at 4.51µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 86 kDa. Observed band size: 86 kDa. |
 | IHC image of PACO57620 diluted at 1:800 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of HepG2 cells with PACO57620 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| バックグラウンド: | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acid, c pH. |
| シノニム: | Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1), TRPV2, VRL |
| UniProt Protein Function: | TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, cation; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: cell surface; integral to plasma membrane; plasma membrane; melanosome; endomembrane system Molecular Function:calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity Biological Process: response to temperature stimulus; transport; response to heat; positive regulation of axon extension; sensory perception; transmembrane transport |
| NCBI Summary: | This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5S1 |
| NCBI GenInfo Identifier: | 62901477 |
| NCBI Gene ID: | 51393 |
| NCBI Accession: | Q9Y5S1.1 |
| UniProt Secondary Accession: | Q9Y5S1,Q9Y670, A6NML2, A8K0Z0, |
| UniProt Related Accession: | Q9Y5S1 |
| Molecular Weight: | 85,981 Da |
| NCBI Full Name: | Transient receptor potential cation channel subfamily V member 2 |
| NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily V, member 2 |
| NCBI Official Symbol: | TRPV2 |
| NCBI Official Synonym Symbols: | VRL; VRL1; VRL-1 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily V member 2; OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily V member 2 |
| UniProt Synonym Protein Names: | Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1 |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPV2 |
| UniProt Entry Name: | TRPV2_HUMAN |
| Antibodies |
| Anti-TRPV2 Antibody (CAB12367) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
