Description
| 抗体名: | TRAF4 Antibody (PACO22764) |
| 抗体コード: | PACO22764 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from internal of human TRAF4. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 3T3 cells, using TRAF4 antibody. |
| バックグラウンド: | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract By similarity. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. |
| シノニム: | TNF receptor-associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Malignant 62; RING finger protein 83; TRAF4 |
| UniProt Protein Function: | TRAF4: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Belongs to the TNF receptor-associated factor family. B subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q11-q12 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein binding; thioesterase binding; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; WW domain binding Biological Process: positive regulation of JNK cascade; positive regulation of protein kinase activity; signal transduction |
| NCBI Summary: | This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BUZ4 |
| NCBI GenInfo Identifier: | 30580636 |
| NCBI Gene ID: | 9618 |
| NCBI Accession: | Q9BUZ4.1 |
| UniProt Secondary Accession: | Q9BUZ4,O75615, Q14848, Q2KJU4, Q2PJN8, |
| UniProt Related Accession: | Q9BUZ4 |
| Molecular Weight: | 22,841 Da |
| NCBI Full Name: | TNF receptor-associated factor 4 |
| NCBI Synonym Full Names: | TNF receptor associated factor 4 |
| NCBI Official Symbol: | TRAF4 |
| NCBI Official Synonym Symbols: | CART1; MLN62; RNF83 |
| NCBI Protein Information: | TNF receptor-associated factor 4 |
| UniProt Protein Name: | TNF receptor-associated factor 4 |
| UniProt Synonym Protein Names: | Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; MLN 62; RING finger protein 83 |
| Protein Family: | TNF receptor-associated factor |
| UniProt Gene Name: | TRAF4 |
| UniProt Entry Name: | TRAF4_HUMAN |
