Description
| 抗体名: | TPP2 Antibody (PACO44313) |
| 抗体コード: | PACO44313 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Tripeptidyl-peptidase 2 protein (1-300AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: TPP2antibody at 3.42µg/ml. Lane 1: Hela whole cell lysate. Lane 2: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 138 kDa. Observed band size: 138 kDa.. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO44313 at dilution of 1:100. |
| バックグラウンド: | Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity). |
| シノニム: | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II), TPP2 |
| UniProt Protein Function: | TPP2: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Belongs to the peptidase S8 family. |
| UniProt Protein Details: | Protein type:EC 3.4.14.10; Protease Chromosomal Location of Human Ortholog: 13q32-q33 Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus Molecular Function:tripeptidyl-peptidase activity; serine-type endopeptidase activity; endopeptidase activity; aminopeptidase activity Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; proteolysis |
| NCBI Summary: | This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29144 |
| NCBI GenInfo Identifier: | 34223721 |
| NCBI Gene ID: | 7174 |
| NCBI Accession: | P29144.4 |
| UniProt Secondary Accession: | P29144,Q5VZU8, |
| UniProt Related Accession: | P29144 |
| Molecular Weight: | 1249 |
| NCBI Full Name: | Tripeptidyl-peptidase 2 |
| NCBI Synonym Full Names: | tripeptidyl peptidase II |
| NCBI Official Symbol: | TPP2 |
| NCBI Official Synonym Symbols: | TPP-2 |
| NCBI Protein Information: | tripeptidyl-peptidase 2; TPP-II; tripeptidyl-peptidase II; tripeptidyl aminopeptidase |
| UniProt Protein Name: | Tripeptidyl-peptidase 2 |
| UniProt Synonym Protein Names: | Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II; TPP-II |
| Protein Family: | Tripeptidyl-peptidase |
| UniProt Gene Name: | TPP2 |
| UniProt Entry Name: | TPP2_HUMAN |
