| UniProt Protein Function: | TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q23.1 Cellular Component: cytoplasm Molecular Function:caspase inhibitor activity Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of caspase activity; negative regulation of apoptosis |
| UniProt Code: | O95379 |
| NCBI GenInfo Identifier: | 74735587 |
| NCBI Gene ID: | 25816 |
| NCBI Accession: | O95379.1 |
| UniProt Secondary Accession: | O95379,Q9P1Q1, Q9UER5, Q9UP47, B3KMH1, B3KMI2, B7Z713 |
| UniProt Related Accession: | O95379 |
| Molecular Weight: | 24,385 Da |
| NCBI Full Name: | Tumor necrosis factor alpha-induced protein 8 |
| NCBI Synonym Full Names: | tumor necrosis factor, alpha-induced protein 8 |
| NCBI Official Symbol: | TNFAIP8 |
| NCBI Official Synonym Symbols: | NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13 |
| NCBI Protein Information: | tumor necrosis factor alpha-induced protein 8; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein |
| UniProt Protein Name: | Tumor necrosis factor alpha-induced protein 8 |
| UniProt Synonym Protein Names: | Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 |
| Protein Family: | Tumor necrosis factor alpha-induced protein |
| UniProt Gene Name: | TNFAIP8 |
| UniProt Entry Name: | TFIP8_HUMAN |
