| UniProt Protein Function: | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| NCBI Summary: | The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UKI8 |
| NCBI GenInfo Identifier: | 34223086 |
| NCBI Gene ID: | 9874 |
| NCBI Accession: | Q9UKI8.2 |
| UniProt Secondary Accession: | Q9UKI8,Q14150, Q8N591, Q9NYH2, Q9Y4F6, B3KR15, B4DX87 |
| UniProt Related Accession: | Q9UKI8 |
| Molecular Weight: | 81,927 Da |
| NCBI Full Name: | Serine/threonine-protein kinase tousled-like 1 |
| NCBI Synonym Full Names: | tousled like kinase 1 |
| NCBI Official Symbol: | TLK1 |
| NCBI Official Synonym Symbols: | PKU-beta |
| NCBI Protein Information: | serine/threonine-protein kinase tousled-like 1 |
| UniProt Protein Name: | Serine/threonine-protein kinase tousled-like 1 |
| UniProt Synonym Protein Names: | PKU-beta; Tousled-like kinase 1 |
| Protein Family: | Serine/threonine-protein kinase tousled |
| UniProt Gene Name: | TLK1 |
| UniProt Entry Name: | TLK1_HUMAN |
