Description
| 抗体名: | TLE4 Antibody (PACO57076) |
| 抗体コード: | PACO57076 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Transducin-like enhancer protein 4 protein (284-394AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of Hela cells with PACO57076 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| バックグラウンド: | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). |
| シノニム: | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4), TLE4, GRG4 KIAA1261 |
| UniProt Protein Function: | TLE4: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. In all tissues examined, mostly in brain, and muscle. Belongs to the WD repeat Groucho/TLE family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 9q21.31 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding |
| UniProt Code: | Q04727 |
| NCBI GenInfo Identifier: | 158518541 |
| NCBI Gene ID: | 7091 |
| NCBI Accession: | Q04727.3 |
| UniProt Secondary Accession: | Q04727,Q3ZCS1, Q5T1Y2, Q6PCB3, Q9BZ07, Q9BZ08, Q9BZ09 Q9NSL3, Q9ULF9, F8W6T6, |
| UniProt Related Accession: | Q04727 |
| Molecular Weight: | 81,011 Da |
| NCBI Full Name: | Transducin-like enhancer protein 4 |
| NCBI Synonym Full Names: | transducin like enhancer of split 4 |
| NCBI Official Symbol: | TLE4 |
| NCBI Official Synonym Symbols: | ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI) |
| NCBI Protein Information: | transducin-like enhancer protein 4 |
| UniProt Protein Name: | Transducin-like enhancer protein 4 |
| UniProt Synonym Protein Names: | Grg-4; Groucho-related protein 4 |
| Protein Family: | Transducin-like enhancer protein |
| UniProt Gene Name: | TLE4 |
| UniProt Entry Name: | TLE4_HUMAN |
| Antibodies | ELISA Kits |
| Anti-TLE4 Antibody (CAB18345) | TLE4 Colorimetric Cell-Based ELISA |
| TLE4 Antibody (PACO01633) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
