Description
| Product Name: | Thymosin beta 4 Recombinant Protein |
| Product Code: | RPPB1379 |
| Size: | 5mg |
| Target: | Thymosin beta 4 |
| Synonyms: | Thymosin beta-4, T beta 4, Fx , TB4X, PTMB4, TMSB4. |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Thymosin b4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution T beta 4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by RP-HPLC. |
| Amino Acid Sequence: | Thymosin b4 has an aa sequence of Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH |
Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system.Thymosin also assists in the development of B cells to plasma cells to produce antibodies.The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin.
Thymosin b4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. It has a molecular weight of 4963.55 Da, and its molecular formula is: C212H350N56O78S1. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation.
| UniProt Protein Function: | TMSB4X: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: Xq21.3-q22 Cellular Component: cytoskeleton; extracellular region Molecular Function:actin monomer binding; protein binding Biological Process: platelet activation; platelet degranulation; sequestering of actin monomers; actin filament organization; blood coagulation |
| NCBI Summary: | This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62328 |
| NCBI GenInfo Identifier: | 78103211 |
| NCBI Gene ID: | 7114 |
| NCBI Accession: | P62328.2 |
| UniProt Secondary Accession: | P62328,P01253, P01254, Q546P5, Q63576, Q9UE55, |
| UniProt Related Accession: | P62328 |
| Molecular Weight: | 44 |
| NCBI Full Name: | Thymosin beta-4 |
| NCBI Synonym Full Names: | thymosin beta 4, X-linked |
| NCBI Official Symbol: | TMSB4X�� |
| NCBI Official Synonym Symbols: | FX; TB4X; PTMB4; TMSB4�� |
| NCBI Protein Information: | thymosin beta-4; t beta-4; prothymosin beta-4; thymosin, beta 4, X chromosome |
| UniProt Protein Name: | Thymosin beta-4 |
| UniProt Synonym Protein Names: | FxHematopoietic system regulatory peptideAlternative name(s):Seraspenide |
| Protein Family: | Thymosin |
| UniProt Gene Name: | TMSB4X�� |
| UniProt Entry Name: | TYB4_HUMAN |
