Description
| Product Name: | Thymosin ?1 Recombinant Protein |
| Product Code: | RPPB1378 |
| Size: | 5mg |
| Target: | Thymosin ?1 |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 99.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
Thymosin a1 acetate, also known as thymalfasin has immunoregulatory properties enhancing immune functions. Thymosin a1 has a molecular formula of C129H215N33O55 a.a. sequence of Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH and having a Mw of 3108.32 Dalton.
| UniProt Protein Function: | PTMA: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: transcription, DNA-dependent |
| UniProt Code: | P06454 |
| NCBI GenInfo Identifier: | 135834 |
| NCBI Gene ID: | 5757 |
| NCBI Accession: | P06454.2 |
| UniProt Secondary Accession: | P06454,Q15249, Q15592, |
| UniProt Related Accession: | P06454 |
| Molecular Weight: | 12,074 Da |
| NCBI Full Name: | Prothymosin alpha |
| NCBI Synonym Full Names: | prothymosin, alpha |
| NCBI Official Symbol: | PTMA�� |
| NCBI Official Synonym Symbols: | TMSA�� |
| NCBI Protein Information: | prothymosin alpha |
| UniProt Protein Name: | Prothymosin alpha |
| Protein Family: | Prothymosin |
| UniProt Gene Name: | PTMA�� |
| UniProt Entry Name: | PTMA_HUMAN |
