| UniProt Protein Function: | TFF2: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: extracellular space Molecular Function:protein binding Biological Process: digestion; wound healing |
| NCBI Summary: | Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03403 |
| NCBI GenInfo Identifier: | 2833194 |
| NCBI Gene ID: | 7032 |
| NCBI Accession: | Q03403.2 |
| UniProt Secondary Accession: | Q03403,Q15854, |
| UniProt Related Accession: | Q03403 |
| Molecular Weight: | 14,284 Da |
| NCBI Full Name: | Trefoil factor 2 |
| NCBI Synonym Full Names: | trefoil factor 2 |
| NCBI Official Symbol: | TFF2 |
| NCBI Official Synonym Symbols: | SP; SML1 |
| NCBI Protein Information: | trefoil factor 2 |
| UniProt Protein Name: | Trefoil factor 2 |
| UniProt Synonym Protein Names: | Spasmolysin; Spasmolytic polypeptide; SP |
| Protein Family: | Splenin |
| UniProt Gene Name: | TFF2 |
