Description
| 抗体名: | TFEB Antibody (PACO43502) |
| 抗体コード: | PACO43502 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Transcription factor EB protein (1-220AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: Transcription factor EB antibody at 3µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53, 44 kDa. Observed band size: 53 kDa. |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43502 at dilution of 1:100. |
| バックグラウンド: | Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. |
| シノニム: | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35), TFEB, BHLHE35 |
| UniProt Protein Function: | TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21 Cellular Component: cytoplasm; nucleus Molecular Function:transcription factor activity Biological Process: embryonic placenta development; humoral immune response; lysosome organization and biogenesis; positive regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | P19484 |
| NCBI GenInfo Identifier: | 19856774 |
| NCBI Gene ID: | 7942 |
| NCBI Accession: | P19484.3 |
| UniProt Secondary Accession: | P19484,Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8, |
| UniProt Related Accession: | P19484 |
| Molecular Weight: | 43,803 Da |
| NCBI Full Name: | Transcription factor EB |
| NCBI Synonym Full Names: | transcription factor EB |
| NCBI Official Symbol: | TFEB |
| NCBI Official Synonym Symbols: | TCFEB; BHLHE35; ALPHATFEB |
| NCBI Protein Information: | transcription factor EB |
| UniProt Protein Name: | Transcription factor EB |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 35; bHLHe35 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFEB |
| UniProt Entry Name: | TFEB_HUMAN |
| Antibodies |
| Anti-TFEB Antibody (CAB11796) |
| Anti-TFEB Antibody (CAB7311) |
| TFEB Antibody (PACO06990) |
| TFEB Antibody (PACO12715) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
