Description
| 抗体名: | TENM1 Antibody (PACO63523) |
| 抗体コード: | PACO63523 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Teneurin-1 protein (1-241AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63523 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| バックグラウンド: | Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). |
| シノニム: | Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)], TENM1, ODZ1 TNM1 |
| UniProt Protein Function: | ODZ1: May function as a cellular signal transducer. Belongs to the tenascin family. Teneurin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq25 Cellular Component: cytoplasm; cytoskeleton; endoplasmic reticulum; extracellular region; Golgi apparatus; integral to plasma membrane; nuclear matrix; nuclear speck; nucleus; perinuclear region of cytoplasm; plasma membrane Molecular Function:heparin binding; protein heterodimerization activity; protein homodimerization activity Biological Process: immune response; negative regulation of cell proliferation; nervous system development; neuropeptide signaling pathway; positive regulation of actin filament polymerization; positive regulation of filopodium formation; positive regulation of MAP kinase activity; positive regulation of peptidyl-serine phosphorylation; regulation of transcription from RNA polymerase III promoter; transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9UKZ4 |
| NCBI GenInfo Identifier: | 110347400 |
| NCBI Gene ID: | 10178 |
| NCBI Accession: | NP_055068.2 |
| UniProt Secondary Accession: | Q9UKZ4,Q5JZ17, B2RTR5, |
| UniProt Related Accession: | Q9UKZ4 |
| Molecular Weight: | 305,947 Da |
| NCBI Full Name: | teneurin-1 isoform 3 |
| NCBI Synonym Full Names: | teneurin transmembrane protein 1 |
| NCBI Official Symbol: | TENM1 |
| NCBI Official Synonym Symbols: | TNM; ODZ1; ODZ3; TNM1; TEN-M1 |
| NCBI Protein Information: | teneurin-1 |
| UniProt Protein Name: | Teneurin-1 |
| UniProt Synonym Protein Names: | Protein Odd Oz/ten-m homolog 1; Tenascin-M1; Ten-m1 |
| UniProt Gene Name: | TENM1 |
| UniProt Entry Name: | TEN1_HUMAN |
