Description
| 抗体名: | TCL1A Antibody, HRP conjugated (PACO46279) |
| 抗体コード: | PACO46279 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human T-cell leukemia/lymphoma protein 1A protein (1-90AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. |
| シノニム: | T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1), TCL1A, TCL1 |
| UniProt Protein Function: | TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family. |
| UniProt Protein Details: | Protein type:Oncoprotein; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 14q32.1 Cellular Component: endoplasmic reticulum; pronucleus; cell cortex Molecular Function:protein binding Biological Process: multicellular organismal development; stem cell maintenance |
| NCBI Summary: | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
| UniProt Code: | P56279 |
| NCBI GenInfo Identifier: | 3024699 |
| NCBI Gene ID: | 8115 |
| NCBI Accession: | P56279.1 |
| UniProt Related Accession: | P56279 |
| Molecular Weight: | |
| NCBI Full Name: | T-cell leukemia/lymphoma protein 1A |
| NCBI Synonym Full Names: | TCL1 family AKT coactivator A |
| NCBI Official Symbol: | TCL1A |
| NCBI Official Synonym Symbols: | TCL1 |
| NCBI Protein Information: | T-cell leukemia/lymphoma protein 1A |
| UniProt Protein Name: | T-cell leukemia/lymphoma protein 1A |
| UniProt Synonym Protein Names: | Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1 |
| Protein Family: | MYB-like transcription factor |
| UniProt Gene Name: | TCL1A |
| UniProt Entry Name: | TCL1A_HUMAN |
