Description
| 抗体名: | TCEB3 Antibody |
| 抗体コード: | PACO00754 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the Internal region of human Elongin A1. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | TCEB3; MSTP059; Transcription elongation factor B polypeptide 3; Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110 |
| UniProt Protein Function: | TCEB3: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 1p36.1 Cellular Component: nucleoplasm; extracellular space; cytoplasm; integral to membrane; nucleus Molecular Function:DNA binding Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression |
| NCBI Summary: | This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14241 |
| NCBI GenInfo Identifier: | 294862430 |
| NCBI Gene ID: | 6924 |
| NCBI Accession: | Q14241.2 |
| UniProt Related Accession: | Q14241 |
| Molecular Weight: | ~ 105kDa |
| NCBI Full Name: | Elongin-A |
| NCBI Synonym Full Names: | elongin A |
| NCBI Official Symbol: | ELOA |
| NCBI Official Synonym Symbols: | SIII; TCEB3; TCEB3A; SIII p110 |
| NCBI Protein Information: | elongin-A |
| UniProt Protein Name: | Transcription elongation factor B polypeptide 3 |
| UniProt Synonym Protein Names: | Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110 |
| Protein Family: | Protein |
| UniProt Gene Name: | TCEB3 |
| UniProt Entry Name: | ELOA1_HUMAN |
